Reflections on the 2023 AACR Conference
Reflecting on the AACR General Conference 2023, Orlando, Florida To start the 2023 AACR meeting, AACR CEO Margaret Foti welcomed everyone and gave opening remarks. She said as the number of cancers around the world are increasing, it is leading to the pursuit of transformative research. She emphasized the need for collaborative studies between cancer […]
What is DNA Nanoball Sequencing?
DNA Nanoball Sequencing DNBSEQ™ DNA nanoball sequencing (DNBSEQ™) is a cutting-edge method for sequencing DNA that has gained popularity in recent years as an alternative to the bridge amplification method used by Illumina instruments. DNA nanoball sequencing uses a combination of nanotechnology, polymerase amplification, and fluorescent imaging to sequence DNA with high accuracy and throughput. […]
Decoding Colorectal Cancer: The Power of Gene Expression Analysis in Molecular Subtype Classification
Introduction: Colorectal cancer (CRC) is a prevalent and deadly disease with diverse clinical outcomes and responses to treatment. Traditionally, CRC has been classified based on anatomical and histological features. However, recent advancements in gene expression analysis have revolutionized our understanding of CRC’s molecular landscape, leading to the identification of distinct molecular subtypes. In this blog post, […]
Unveiling Tumor Microenvironment Dynamics: Stereo-seq Sheds Light on Liver Cancer Progression
Stereo-seq Stands Out Among Spatial Transcriptomics Platforms A recently published paper titled “An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte-tumor cell crosstalk, local immunosuppression and tumor progression” by Wu et. al. shows how liver tumor cells interact with the surrounding microenvironment during cancer progression(1). The study, available in the journal Cancer […]
History of Spatial Transcriptomics Part 3 – Single Cell
To achieve single cell resolution, NanoString developed another platform, CosMx SMI (Single Molecule Imaging), with a resolution of 1um, enabling it to detect transcripts at the subcellular level. The main limitation of CosMx is that it is constrained to ~1000 probes in each panel. This requires one to customize the probe set for each study based on […]
History of Spatial Transcriptomics Part 2 – Spatial Transcriptomics of Tissue Regions
To overcome the limitation of only being able to study gene expression in areas of a tissue that were isolated by LCM, a group at The Spatial Research Lab at the Science for Life Laboratory developed a novel slide-based transcriptomics approach. This group was led by Drs. Joakim Lundeberg, Stefania Giacomello, and Patrik Ståhl (14). […]
History of Spatial Transcriptomics Part 1 – Single Gene Spatial Transcriptomics
The function of complex multicellular organisms depends on the spatial organization of their cells. It is accepted that all cells in an organism (except for germ cells and lymphocytes ) have the same genetic make-up. Then, what contributes to diversity of cells and their function? Mostly, differential gene expression. Thus, the study of the spatial […]
Exploring Frontiers in Genomics: Previewing The PAG 31 Conference
The 2024 International Plant & Animal Genome Conference (PAG 31) For over three decades, the Plant and Animal Genome Conference (PAG) has been a meeting known for fostering collaboration, and showcasing groundbreaking advancements in the fields of plant and animal genomics. Established in 1993, PAG has evolved into a conference that converges experts, emerging talents, […]
Highlights for the 2024 AACR Annual Meeting
The American Association for Cancer Research (AACR) Annual Meeting is one of the most anticipated events in the field of oncology, bringing together researchers, clinicians, industry professionals, and advocates to share groundbreaking discoveries and advancements in cancer research. The theme of the AACR Annual Meeting 2024, “Inspiring Science, Fueling Progress, Revolutionizing Care,” sets the tone […]